Cody Zeller poured in a game-high 19 points on 7-of-12 shooting and grabbed 10 rebounds as No. 5 Indiana held off Iowa, 69-65, on Monday at Carver-Hawkeye Arena.
Victor Oladipo netted 14 points on 6-of-10 from the floor and pulled down 10 boards, while Will Sheehey contributed 13 points and five rebounds off the bench for Indiana (13-1, 1-0 Big Ten), which snapped a four-game losing streak against the Hawkeyes in Iowa City.
Christian Watford gave 11 points and eight boards in the triumph.
"We know this is a huge win for us coming in here," Indiana coach Tom Crean said of winning at Iowa. "I haven't seen a lot of teams in the Big Ten play a lot of different games, but I like watching Iowa play. They play so hard. They're competitive."
Aaron White paced the Hawkeyes (11-3, 0-1) with 15 points and six rebounds, while Roy Devyn Marble added 14 points and nine rebounds. Marble struggled mightily from the floor, hitting just 1-of-14 field goal attempts, but made 12-of-13 from the free throw line.
Mike Gesell finished with 13 points for Iowa, which had a six-game winning streak snapped.
Trailing 57-54 with 6:58 to play, Zach McCabe buried a jumper to move the Hawkeyes within one, but Sheehey answered with a corner 3-ball for Indiana, making it 59-56 with 5:17 on the clock.
Marble sank two of his 13 free throw attempts with 2:05 to go, pulling Iowa within 63-60, but Oladipo came up with a huge basket for Indiana on its next trip down the floor when he hauled in a Zeller miss and put it back to make it a two-possession game with 1:03 left.
Josh Oglesby nailed a deep trey with seven ticks left to make it 68-65, but the Hawkeyes were forced to foul, and sent Watford to the charity stripe with five seconds left.
Watford missed his first attempt, but made the all-important second shot to seal the win for the Hoosiers.
Early on, Indiana jumped out to a quick 7-2 lead, but the Hawkeyes roared back with a 14-4 burst to grab a 16-11 advantage with 9:52 on the first-half clock.
Indiana answered with a lengthy run of its own, outscoring Iowa 18-4 over the next five-plus minutes of action to move ahead, 29-20 with 3:11 to go and the visitors took a 33-25 lead into the locker room.
Indiana owns a 96-74 advantage in the all-time series with Iowa ... Indiana shot just 40 percent from the floor, but held Iowa to 33.3 percent from the field ... The Hoosiers received 16 points from its reserves, while the Hawkeyes bench posted 13 points.