Tricia Liston scored 15 points for No. 4 Duke, and Monmouth tied a Division I record with three points in the first half of a 73-32 rout Sunday.
The overmatched Hawks managed just one field goal in the opening 20 minutes against the Blue Devils (11-0).
Monmouth (3-8) matched the NCAA's halftime scoring mark set in 2003 by Savannah State against Florida State and equaled by Tennessee State two years ago against Georgia Tech.
Chelsea Gray scored 13 points and Haley Peters added 11 points and 10 rebounds for the Blue Devils, who could afford an off day from star sophomore Elizabeth Williams.
She had 11 rebounds but matched a career low with seven points — nine below her average — on 1-of-7 shooting.