Jim Harbaugh kept his sentences short and information at a minimum Monday, repeating a phrase he will rely on following the worst loss of his NFL coaching career: regroup, refit and reorganize.

That's all the San Francisco 49ers can do at this point.

Beat up and beat down, San Francisco's 42-13 blowout loss at Seattle cost the 49ers (10-4-1) more than just a game. They have another pair of key starters questionable with injuries, let control of a first-round playoff bye slip away and head into the regular-season finale at home against Arizona (5-10) with a slim half-game lead in the NFC West.

The only way the 49ers can secure a No. 2 playoff seed — and the first-round bye that comes with it — is a win against the Cardinals coupled with a Green Bay loss at Minnesota. And they could have to do it with tight end Vernon Davis (concussion) and wide receiver Mario Manningham (left knee) the latest starters to join a growing injury list.

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