Skylar Diggins posted 22 points and eight assists as No. 5 Notre Dame took an 87-57 win over Kansas State on Thursday.
Natalie Achonwa posted 13 points while Kayla McBride added 12 points for the Irish (8-1), who have won three straight after losing to Baylor.
Brittany Chambers gave 18 points and seven rebounds while Haley Texada added 11 points for the Wildcats (7-3), who have dropped their past three games.
Diggins was on fire early as she scored 11 of Notre Dame's first 17 points, with her layup giving the team a 17-5 lead 5 1/2 minutes in.
A 9-0 run a bit later made it a 28-10 game and the Irish eventually took a 49-25 lead into the break.
Notre Dame's lead never fell below 21 points in the second half.