Champions League favorite Barcelona has been drawn to play AC Milan in the last-16 round, and nine-time winner Real Madrid will face Manchester United in another blockbuster clash.
Arsenal faces Bayern Munich, last season's runner-up, and big-spending Paris Saint-Germain plays Valencia.
Italian champion Juventus will play Celtic, and debutant Malaga plays FC Porto.
Also, it was: Shakhtar Donetsk vs. Borussia Dortmund and Galatasaray vs. Schalke.
First-leg matches are played from February 12-20. Return matches are from March 5-13.