The Indianapolis Colts will be without a pair of offensive line starters in center Samson Satele and tackle Winston Justice for Sunday's matchup with the AFC South-leading Houston Texans.
Satele has started every game he has played in this season, his first in Indianapolis and sixth in the NFL. He is suffering from an ankle injury that kept him out of practice all week.
Justice, who is dealing with a biceps injury, is also in his first season in Indy after a six-year stint with the Philadelphia Eagles and has started 11 games this year. He has not practiced all week as well.
Running back Delone Carter (ankle), linebacker Kavell Conner (hamstring) and safety Tom Zbikowski (knee) have also been ruled out for Sunday's game.
The Colts can wrap up a spot in the playoffs with a win, but are two games behind Houston in the AFC South race with three to play. The division rivals also play in Houston in the regular-season finale in two weeks.