The Indianapolis Colts placed running back Donald Brown on injured reserve Tuesday and signed running backs Deji Karim and Mewelde Moore to the active roster.
Brown totaled 417 yards and one touchdown on 108 carries over 10 games (four starts) for the Colts this season, but was hampered by knee and ankle injuries throughout the year.
A first-round selection of the Colts in 2009, Brown has compiled 1,840 yards and 11 touchdowns on 449 carries over four seasons in Indianapolis.
Moore signed with the Colts as a free agent in June, but was waived on Oct. 29 after carrying the ball just nine times for 14 yards through six games.
A nine-year veteran, Moore has racked up 2,261 yards and six rushing scores on 503 carries over 119 games with Minnesota, Pittsburgh and the Colts.
Karim has appeared in 23 games over his three-year career, recording 98 rushes for 290 yards and 17 receptions for 130 yards.
The Colts also placed fullback Robert Hughes on injured reserve Tuesday and signed running back Davin Meggett to the practice squad to replace running back Alvester Alexander, who was released from the practice squad.