Siyani Chambers scored 17 of his 21 points in the second half and hit the game-winning jumper with 4 seconds left to lift Harvard past Boston University 65-64 Tuesday night.
Wesley Saunders chipped in with 16 points to help Harvard (5-4) win its fourth game in a row against Boston.
Trailing 62-60 late in the second half, Boston (3-6) tied the game on Dom Morris' layup with 1:13 left to play.
Harvard answered with 46 seconds left when Saunders made 1 of 2 free throws to give the Crimson the lead 63-62.
D.J. Irving's jumper put Boston ahead 64-63 with only 9 seconds left, but Chambers responded, connecting with the game-winning jumper with just 4 ticks remaining.
Irving missed a jumper as time expired, sealing the victory for Harvard.
Irving led Boston with 24 points and Morris added a double-double, 15 points and 12 rebounds.