Sean O'Hair and Kenny Perry combined to fire an 11-under 61 on Saturday and that gave the pair a 2-stroke lead after two rounds of the Franklin Templeton Shootout.
The duo finished 36 holes at 19-under-par 125. O'Hair is looking for his first win at this event, while Perry has won the crown twice. Perry won with John Huston in 2005 and with Scott Hoch in 2008.
The second round had the field competing in the better-ball format. Sunday's final round will have the teams playing a scramble.
U.S. Ryder Cup captain Davis Love III and one of his captain's picks, Brandt Snedeker, carded a 7-under 65. The first-round leaders dropped into second place at minus-17 on the Gold Course at Tiburon Golf Club.
Stewart Cink and Carl Pettersson fired a 10-under 62 to end two rounds tied for third at 15-under-par 129. They were joined there by the teams of Charles Howell III and Rory Sabbatini, and Jason Dufner and Vijay Singh. Those two tandems carded 9-under 63s on Saturday.
Jerry Kelly and Steve Stricker, the 2009 champions, shot 9-under 63 to match last year's winners Keegan Bradley and Brendan Steele (64) in sixth place at 13-under 131.
O'Hair rolled in a 10-footer for birdie at the seventh. Around the turn, he chipped in for birdie at No. 13 to get his team to 14-under and within one of the lead.
Shortly after that, play was halted by a heavy rainstorm. After play resumed, O'Hair and Perry remained on fire.
Perry 2-putted for birdie from just short of the green on the 14th. That gave them a share of the lead. Perry poured in a 20-foot birdie effort at 15 before O'Hair took over.
The 2011 Canadian Open winner converted a 5-foot birdie chance at 16 to give his team a 1-shot lead. O'Hair got up and down for birdie on No. 17 as he and Perry remained one ahead.
At the last, Perry drained a 8-foot birdie effort to give his team a 2-shot lead. That was the sixth birdie in a row for the duo.
"Our mindset is just to have two putts at it everytime," O'Hair said in a televised interview. "Tomorrow, we're just going to go all out and just try and birdie every hole."
Snedeker birdied the seventh from four feet out and the 10th from 12 feet away. He also converted a birdie try on the 12th to push his team ahead by two.
As O'Hair and Perry made their charge, Snedeker tried to help his team keep pace with an 8-foot birdie effort on No. 15.
Dustin Johnson and Ian Poulter, the 2010 champions, carded a 7-under 65 and are alone in eighth at 12-under-par 132. Bud Cauley and Rickie Fowler are one stroke back at minus-11 after posting a 67 on Saturday.
Justin Leonard and Scott Verplank, who have finished second at this event twice, carded a 67 to end two rounds at minus-7. Fredrik Jacobson and tournament-host Greg Norman (68) are in 11th at 4-under 140, while Mark Calcavecchia and Mike Weir (71) are in last place at 3-under 141.
NOTES: Love, Calcavecchia, Norman, and Kelly have all won this title in the past ... This is the final off-season event for the PGA Tour.