Frank Kramer's first match in charge of Hoffenheim didn't end well on Friday as Artjoms Rudnevs scored a goal in each half to lead Hamburg to a 2-0 win over Kramer's team at the HSH Nordbank Arena.
Markus Babbel was dismissed as Hoffenheim manager earlier this week, but his replacement faired no better on Friday as Rudnevs scored midway through the first half and added to his tally 15 minutes from time, moving Hamburg into the top half of the league.
Hoffenheim has won just three of its first 16 Bundesliga games, and after generating a few chances early on, the team went behind in the 28th minute.
Dennis Diekmeier provided the cross and Rudnevs got up to head the ball beyond the reach of Hoffenheim goalkeeper Koen Casteels.
The hosts nearly doubled their lead 10 minutes later, but Tolgay Arslan's shot crashed against the crossbar.
Hoffenheim was unable to mount a serious threat, and Rudnevs made it 2-0 when he pounced on a poor clearance from Sebastian Rudy to smack home his second goal of the match.
Bayern Munich intends to maintain its eight-point lead at the top of the Bundesliga when the club visits second-from-the-bottom Augsburg, while second- place Bayer Leverkusen attempts to keep pace with a win at mid-table Hannover.
Borussia Dortmund hosts Wolfsburg with the club having won its Champions League group, Schalke tries to snap a four-game winless streak when the club visits Stuttgart.
Eintracht enters the weekend in the top five, but must shake off back-to-back losses to get back on track, which the club hopes to do at home against Werder Bremen.
Dusseldorf travels to Nurnberg with the two sides separated by two points in the bottom half of the league, last-place Greuther Furth visits Freiburg and Monchengladbach entertains Mainz.