Samarie Walker and DeNesha Stallworth each recorded a double-double as No. 7 Kentucky rolled over DePaul, 96-64, at Rupp Arena.
Walker poured in a game-high 18 points to go along with 10 rebounds, while Stallworth finished with 17 points and 13 boards for the Wildcats (7-1), who won their sixth straight contest.
A'dia Mathies also netted 17 points with nine rebounds and Jennifer O'Neill scored 13 points in the victory.
Jasmine Penny paced the Blue Demons (6-3) with 16 points, Anna Martin scored 14 and Brittany Hrynko dropped in 13 in DePaul's second loss in three games.
Kentucky wasted no time in taking control as the Wildcats opened the game with a 25-2 run and never looked back.
DePaul never threatened from there as Kentucky carried a comfortable 51-33 lead into the break and cruised through the second half.