Murphy Holloway scored 23 points and added eight rebounds as Mississippi placed four players in double figures Friday to defeat Lipscomb 91-45.
Nick Williams scored 14 points for the Rebels (5-0), while Reginald Buckner and Marshall Henderson added 10 apiece. Ole Miss led 17-2 in the opening 4 minutes and was never seriously threatened.
Stephen Hurt led Lipscomb (2-2) with 14 points and seven rebounds while John Ross Glover added 12 points. The Bisons struggled from the field, managing only 12 of 49 (24.5 percent).
Ole Miss led 43-22 at halftime and by more than 30 points for most of the second half. The Rebels were 30 of 69 (43.5 percent) from the field and outrebounded the Bisons 43-38.
The Rebels improved to 56-2 against nonconference opponents at home during Andy Kennedy's seven-year tenure.