Rubin locked up the top spot in Group H of the Europa League on Thursday as Salomon Rondon scored twice to help the Russian side to a 3-0 win over Inter Milan at Tsentralnyi Stadium.
The two teams entered the contest level on 10 points having already secured advancement to the next round, but Rubin took advantage of a slightly inexperienced Italian side to finish on top of the group.
Gokdeniz Karadeniz scored in the opening minute for Rubin after Inter's Juan Jesus struck his own post with a clearance attempt, allowing Gokdeniz Karadeniz to easily score from close range.
The young Inter squad pressed Rubin, but goalkeeper Sergei Ryzhikov came up big to keep his team in front, and Rondon secured the win with two goals over the final three minutes.
Rondon buried his first goal by finding the roof of the net from 12 yards before he capped the win after being played in on goal by Gokdeniz Karadeniz.
The other contest in the group saw Aleksandar Mitrovic score the equalizer in the 67th minute for Partizan Belgrade at Neftchi.
Anzhi holds a three-point lead at the top of Group A after a 2-0 win over Udinese that saw Christopher Samba and Samuel Eto'o score goals in the second half, while Liverpool was denied a big win at Anfield as Elsad Zverotic scored in the 87th minute to help Young Boys claim a 2-2 draw.
Atletico Madrid booked its place in the next round from Group B with a 1-0 win over Hapoel Tel Aviv with Raul Garcia netting the lone goal in the seventh minute. Joining Atletico in the knockout round will be Viktoria Plzen, which traded second-half penalty kicks with Academica in a 1-1 draw.
Fenerbahce maintained its unbeaten record in the competition by securing a 1-0 victory at Marseille to finish on top of Group C, while Igor De Camargo scored two goals in the final 11 minutes of a 2-0 win for Monchengladbach over AEL Limassol that earns the German side second place.
A pair of first-half goals from Jussie helped Bordeaux to a 2-1 win at Brugge and a place in the knockout round out of Group D. And the French side will be joined by Newcastle, which was held to a 1-1 draw at home by Maritimo that clinches the Magpies a top-two place.
In Group E, Stuttgart hammered Steaua Bucharest, 5-1, in Romania, while FC Copenhagen topped Molde, 2-1, behind Rurik Gislason's 79th-minute winner. Those results leave Steaua two points clear at the top of the group with Stuttgart and Copenhagen both still alive.
Ukrainian side Dnipro won for the fourth time in five Europa League matches after beating PSV Eindhoven, 2-1, and Napoli also booked its place in the next round from Group F by topping AIK, 2-1, as Edinson Cavani converted a penalty kick in stoppage time.
FC Basel had little trouble in turning aside Sporting Lisbon, 3-0, while Genk sealed a spot in the top two in Group G by beating Videoton, 2-1.
Lyon won Group I on Thursday after earning a 1-1 draw at Sparta Prague, with the other match in the group between Ironi Kiryat Shmona and Athletic Bilbao in Israel was postponed.
Lazio and Tottenham played to a 0-0 draw in Italy that was enough to give Lazio a spot in the knockout round, while Tottenham sits two points clear of Panathinaikos entering the final day after the Greek side beat Maribor, 1-0, on a second-half penalty kick from Victor Vitolo.
Group K was won by Metalist Kharkiv on Thursday after a 2-0 win over second- place Bayer Leverkusen. The other match in the group saw Rapid Vienna lose for the fifth time in as many matches as the club yielded two goals in the last 13 minutes of a 3-2 defeat at Rosenborg.
Hannover and Levante will represent Group L in the next round after the German side played to a 0-0 draw with Twente and Levante toppled Helsingborg, 3-1, to close to within one point of Hannover at the top.