The Chiefs are without center Ryan Lilja and right guard Jon Asamoah along with wide receiver Jon Baldwin for their game against the Cincinnati Bengals.
Safety Reggie Nelson was inactive for Cincinnati with a hamstring injury Sunday. Taylor Mays is expected to start in his place alongside Nate Clements.
Lilja is inactive with a knee injury and Asamoah had surgery on his right thumb, which caused a major reshuffle of the Chiefs' offensive line. Russ Hochstein will start at center, right tackle Eric Winston will slide to guard and rookie Donald Stephenson will start at tackle.
The Chiefs had already lost center Rodney Hudson to a broken bone in his leg.
Baldwin has not been cleared after a head injury sustained last week against Pittsburgh, though quarterback Brady Quinn is active for the first time since his concussion Oct. 28. He'll serve as the backup to Matt Cassel against the Bengals.