AC Milan's 3-1 home defeat to Fiorentina last weekend dropped the Rossoneri to 13th in Serie A and just five points above the relegation zone.
With only two wins from its last seven league games, Milan manager Massimiliano Allegri and his team have taken plenty of heat in recent weeks, and the club will be desperate to claim three points at third-place Napoli on Saturday.
Milan faces a big Champions League contest at Anderlecht in midweek, and will square off with Serie A leaders Juventus in one week, but first Allegri must get his side back on track.
In Napoli, Milan is facing a side that has had its own troubles in the league recently, winning two of its last five to fall five points back of Juventus.
Saturday's contest also features two of the leading scorers in Serie A as Milan's Stephan El Shaarawy and Napoli's Edinson Cavani sit perched atop the scoring chart with eight goals apiece.
The other contest in Serie A on Saturday features Juventus entertaining fifth- place Lazio, which secured a 3-2 win over Roma last time out in the Rome derby.
Inter Milan lost to Atalanta in its last outing and tries to bounce back with three points at home against Cagliari, while Atalanta tries to continue its push up the table with another victory at fourth-place Fiorentina.
Bologna tries to snap a six-game winless run when the club hosts Palermo, Chievo sits two points above the relegation zone and travels to Catania, Siena and Pescara meet up at the Artemio Franchi in a clash of bottom-half teams, Udinese hosts Parma, Genoa invades Sampdoria and the weekend's action rounds out on Monday with Torino traveling to Roma.