Bayern Munich welcomes Bayer Leverkusen to the Allianz Arena on Sunday, when coach Jupp Heynckes will likely change his lineup for the 14th time in as many matches in all competitions this season.
Franck Ribery (hamstring) and Javi Martinez (groin) were both injured Tuesday in a 1-0 Champions League win over Lille and are doubtful for the fixture this weekend.
For Heynckes, the possible absences of Ribery and Martinez, added to the long- term injuries to Mario Gomez, David Alaba and Arjen Robben, will be easier to compensate for due to the early-season rotation.
"A football team consists of more than 11 players, and everyone will get his chance," Heynckes said. "Rotation has to be accepted."
Bayern is perfect in the Bundesliga this season, with offseason addition Mario Mandzukic leading the league with seven goals and Thomas Muller second on the charts with six.
Mandzukic has helped fill the void left by the injury to Gomez, one of the top scorers in the league over the last few seasons. Muller has returned to great form with more playing time as the result of the injury to Robben.
Robben returned to full training Friday and could play against Leverkusen, but Heynckes was not sure if he would call on the Dutch winger.
"He's trained well, he's free of pain, and he's completed the full program," Heynckes said. "Let's wait and see if he's ready."
Gomez also resumed light training and Heynckes said, "It's looking very good."
Heynckes will not be able to call on the Germany striker this weekend, but the return to health of a number of key players, including Alaba, who played this week, will make Bayern one of the deepest teams in Europe.
Leverkusen sits sixth in the standings and is unbeaten in its last five games, but three of those results are draws. With Bayern a perfect eight-for-eight, a huge task awaits Leverkusen this week on the road.
Eintracht will try to maintain its hold on second when it visits Stuttgart on Sunday. Promoted to the Bundesliga this season, Eintracht was undefeated in its first six matches and rebounded from its first defeat with a victory over Hannover last week to remain five points off the pace.
Schalke sits third and seven points off the pace ahead of its Saturday fixture at home against Nurnberg, while Borussia Dortmund will try to turn a 2-1 win in the Champions League over Real Madrid into domestic success when it visits Freiburg on Saturday.
Also Saturday, Dusseldorf hosts Wolfsburg, Greuther Furth hosts Werder Bremen, and Mainz hosts Hoffenheim. Also Sunday, Hannover hosts Monchengladbach.
On Friday, Heung-Min Son and Artjoms Rudnevs scored as Hamburg beat Augsburg, 2-0, for its third win in its last four matches. Hamburg jumped to fourth in the table ahead of the weekend fixtures. Augsburg is 16th on just six points.