Ohio State and Oregon will play a home-and- home football series starting in 2020 in Eugene.
The Buckeyes will host the Ducks in 2021.
"Oregon has developed into one of the premier football programs in the FBS," Ohio State athletics director Gene Smith said. "We are excited to add them to our future slate of games."
Ohio State also announced it will host the University of Tulsa and Central Michigan in 2016.
Oregon announced it will host Tennessee next season on Sept. 14.