Four-time Pro Bowler Robert Mathis and starting running back Donald Brown did not make the trip when the Indianapolis Colts traveled to New York on Saturday for their game against the Jets.
Neither absence was a surprise. The Colts (2-2) had said both would miss two to three weeks with knee injuries.
Linebacker Jerry Hughes is expected to replace Mathis in the starting lineup, while rookie Vick Ballard is slated to make his first NFL start in place of Brown.
Linebacker Pat Angerer (foot), defensive end Fili Moala (knee) and nose tackle Martin Tevaseu (ankle) also stayed home.
On Friday, interim coach Bruce Arians said starting offensive guard Joe Reitz would miss the game with a knee injury.