New York Jets wide receiver Santonio Holmes left Sunday's 34-0 loss to San Francisco early in the fourth quarter with an injured left foot.
Holmes was hurt after making a short catch on the initial play of the final period. He immediately fell to the ground without being contacted and let go of the ball, which 49ers cornerback Carlos Rogers promptly returned for a 51- yard touchdown that gave San Francisco a 24-0 lead.
The seventh-year veteran was unable to put any weight on his left leg and was carted off the field.
The New York Daily News reported afterward that x-rays on Holmes' foot did come up negative, though the possibility of a serious injury still may exist. He is scheduled to undergo an MRI on Monday.
The Jets had already entered the contest without fellow starting receiver Stephen Hill as well as tight end Dustin Keller, both of whom were declared inactive with hamstring injuries.
Holmes recorded four catches for 29 yards before exiting, one week after coming up with 147 yards on nine grabs in a 23-20 overtime win at Miami on Sept. 23.