Felix Klaus scored in the 67th minute as Greuther Furth defeated Mainz, 1-0, on Friday for its first-ever Bundesliga win.
Furth earned promotion to the top level in Germany for the first time in its history this season, and opened with a 3-0 home loss to record champion Bayern Munich.
But on the road against Mainz in the second week, Klaus notched the lone goal of the match at Coface Arena with deflected shot off Mainz captain Nikolce Noveski.
Two-time defending Bundesliga champion Borussia Dortmund visits Nurnberg to highlight this weekend's Saturday slate. Dortmund claimed its opener against Werder Bremen, 2-1.
Dortmund learned Thursday it will compete in the Champions League group stage against Real Madrid, Manchester City and Ajax, but coach Jurgen Klopp said "Nuremberg were and are the main topic this week."
Marco Reus and Mario Gotze scored in the opener, and Dortmund will try to add to its record 29 straight wins.
On Sunday, Bayern Munich could debut $50 million signing Javi Martinez when it hosts Stuttgart at the Allianz Arena. Martinez, a Spanish midfielder, signed from Athletic Bilbao on Wednesday.
Bayern learned its Champions League fate as well, but the 2012 runner-up has a little easier path, as it was drawn with Valencia, Lille and BATE. Bayern will quickly refocus on the Bundesliga and its home opener.
Germany's other Champions League group-stage participant, Schalke, will host Augsburg on Saturday in search of its first win of the young season. Schalke will do battle with Arsenal, Olympiacos and Montpellier in the group stage.
On Sunday, Hamburg could debut deadline day addition Rafael Van der Vaart when it visits Bremen, Bayer Leverkusen hosts Freiburg, Hoffenheim hosts Eintracht, and Dusseldorf hosts Monchengladbach. Also Sunday, Wolfsburg hosts Hannover.