The Chicago Bears placed rookie safety Brandon Hardin on injured reserve and put wide receiver Johnny Knox on the physically unable to perform list.
Hardin, a third-round pick in the 2012 draft, sustained a neck injury Aug. 18 in the Bears' preseason win over the Washington Redskins.
Knox will be forced to miss the first six weeks of the regular season.
Last December in a game against the Seahawks, Knox suffered a serious back injury. He needed surgery to stabilize a vertebra in his mid-to-lower back.
The Bears also terminated the contract of defensive tackle John McCargo and waived linebacker K.C. Asiodu, quarterback Matt Blanchard, safety Trevor Coston, wide receivers Terriun Crump and Chris Summers and defensive end Derek Walker. Chicago waived/injured linebacker Adrien Cole and guard Nick Pieschel.