Jason Kubel crushed three home runs and knocked in six runs as the Diamondbacks routed the Astros, 12-3, in the second contest of a three-game set Saturday at Chase Field.
Kubel belted a two-run homer in the first, a three-run blast in the fourth and a solo shot in the sixth to lead Arizona to its third win in its last four games.
Kubel now has 46 RBI since June 5, which is tops in the majors.
"You don't see many of those games," said Arizona manager Kirk Gibson of Kubel's performance. "He's got a very short stroke. The way he sets up, he gets the barrel to the ball."
The run support was more than enough for Wade Miley (11-5), who allowed just one run on four hits and two walks with a career-high nine strikeouts. With the victory, Miley set a Diamondbacks single-season rookie record for wins which had been owned by three other players, including Josh Collmenter (2011), Oscar Villarreal (2003) and Brandon Webb (2003).
Dallas Keuchel (1-2) was called up to make the start in place of lefty J.A. Happ, who was sent to the Toronto Blue Jays as part of a 10-player trade on Friday. Keuchel was charged with seven runs -- six earned -- on seven hits and four walks in just 3 1/3 innings.
Chris Johnson and Justin Maxwell each knocked in a run in the setback, Houston's fifth straight and ninth in its last 10 games.
Kubel's opposite-field blast in the first inning barely cleared the wall in left to give the home team a 2-0 lead before Houston got on the board in the fourth when Maxwell ripped a ground-rule double into center field before J.D. Martinez coaxed a walk.
Miley retired the next two Astros, but Johnson came through with a two-out single to right to plate Maxwell and make it a 2-1 contest.
Arizona responded in a big way by plating five runs in the bottom half to build a 7-1 lead.
Chris Young started the frame with a double and Ryan Roberts followed with a walk. Miley then bunted, but Keuchel couldn't field the ball cleanly as Miley reached first to load the bases.
Willie Bloomquist plated the first run with a sacrifice fly and Aaron Hill followed with an RBI single to right to make it a 4-1 game.
Kubel then provided the big blow of the inning as he crushed his second homer of the game -- a three-run shot -- into the seats in right field.
Arizona continued to pile it on in the fifth as Young and Roberts each walked to start the frame. A double steal found runners on second and third and Bloomquist followed two batters later with a line-drive single to center to score Young and Roberts for a 9-1 lead.
Kubel launched his third home run of the game to leadoff the sixth inning as the Diamondbacks grabbed a 10-1 lead.
Maxwell's RBI single in the eighth made it a 10-2 game, but back-to-back RBI doubles from Henry Blanco and Young in the bottom half made it a 10-run difference.
Kubel had a chance for his fourth home run when he led off the bottom of the eighth, but Rhiner Cruz struck him out on four pitches to keep him from history.
Pinch-hitter Carlos Corporan slapped an RBI single in the ninth to account for the final margin.
Keuchel was recalled from Triple-A Oklahoma City to replaced pitcher Brett Myers, who was sent to the Chicago White Sox for pitching prospects Matt Heidenreich and Blair Walters and a player to be named later on Saturday...Arizona reinstated pitcher Takashi Saito from the 15-day disabled list and optioned pitcher Jonathan Albaladejo to Triple-A Reno. Saito allowed a hit, a walk and an unearned run in one inning of work.