Former champion Maria Sharapova eased into the second round, while five-time winner Venus Williams suffered a first- round loss at Wimbledon for the first time in 15 years on Monday.
The world No. 1 Sharapova won her eighth straight Grand Slam match by handling Russian-born Aussie Anastasia Rodionova 6-2, 6-3 on the famed Centre Court at the All England Club.
Sharapova is trying to become the first woman to win the French Open and Wimbledon in the same year since Serena Williams turned the trick 10 years ago. Sharapova captured her first-ever French Open title three weeks ago to become the 10th woman in tennis history to secure the career Grand Slam.
The 25-year-old Sharapova captured her lone Wimbledon championship as a 17- year-old in 2004 and was last year's runner-up here to powerful Czech lefthander Petra Kvitova. The Russian star has appeared in three of the last four major finals (1-2).
Up next for Sharapova will be Bulgarian Tsvetana Pironkova, who reached the semifinals here two years ago and the quarterfinals last year.
Meanwhile, the former world No. 1 Venus succumbed to Russian Elena Vesnina 6-1, 6-3 in 1 hour, 15 minutes on Court 2. Vesnina cruised past a listless Venus in seven games in the first set and got the break she needed for a 4-2 lead in the second and never looked back.
The 32-year-old Venus titled here in 2000, 2001, 2005, 2007 and 2008 and is a three-time Wimbledon runner-up.
She's now 71-11 at tennis' most prestigious event and hadn't lost in the first round here since making her Wimbledon debut in 1997.
"Give credit to her, she played very well," Venus said of the 25-year-old Vesnina, who reached the fourth round at Wimbledon three years ago.
Venus has played sparingly over the last year after being diagnosed with Sjogren's syndrome, an incurable autoimmune disease that causes fatigue and joint pain.
Third-seeded Agnieszka Radwanska earned a 6-3, 6-3 decision over Slovakia's Magdalena Rybarikova, while Sam Stosur, the fifth seed and reigning U.S. Open champion, eased past Spain's Carla Suarez Navarro 6-1, 6-3, and eighth-seeded rising German Angelique Kerber dismissed Czech Lucie Hradecka 6-4, 6-1. The left-handed Kerber was a grass-court finalist in Eastbourne last week.
Radwanska will meet Vesnina in the round of 64.
Eleventh-seeded former French Open champ Li Na of China thumped Ksenia Pervak of Kazakhstan 6-3, 6-1 and 15th-seeded German Sabine Lisicki, a semifinalist last year at the All England Club, cruised to a 6-4, 6-2 victory over Croatia's Petra Martic.
Italy's Camila Giorgi provided the first upset of the tournament with a 6-4, 6-3 win over 16th-seeded countrymate Flavia Pennetta.
In other action involving seeds, No. 23 Czech Petra Cetkovska drubbed American Vania King 6-4, 6-2, France's Stephanie Foretz Gacon knocked out No. 29 Romanian Monica Niculescu 6-4, 3-6, 6-3, and No. 30 Chinese Peng Shuai snuck past Pole Sandra Zaniewska 6-2, 6-7 (3-7), 6-3.