Paris, France –  Six-time champion Rafael Nadal and three- time Grand Slam runner-up Andy Murray, bothered by a back injury on Thursday, were a pair of second-round winners at the French Open.

The second-seeded former world No. 1 Nadal dropped only four games in a 6-2, 6-2, 6-0 pasting of Uzbekistan's Denis Istomin on Court Lenglen. Nadal dropped only five games in his opening-round win on Tuesday.

Nadal is now 47-1 lifetime on the red clay at Roland Garros, including his Open-Era-record-tying six titles. He's currently the reigning two-time champ, including a victory over Roger Federer in last year's finale.

The 10-time major champion Nadal lost to Novak Djokovic in the last three Grand Slam finals.

Nadal's third-round opponent will be Argentine Eduardo Schwank.

The fourth-seeded Murray, meanwhile, received treatments for a bad back and almost retired before recording a 1-6, 6-4, 6-1, 6-2 come-from-behind victory over Finnish veteran Jarkko Nieminen on Court Chatrier.

Murray, who lost to the great Nadal in his first-ever French Open semifinal here a year ago, has now reached the third round in Paris five straight years.

Up next for the British star will be Colombian Santiago Giraldo, who took out 25th-seeded promising Aussie Bernard Tomic 6-4, 6-1, 6-3.

Fifth-seeded French favorite Jo-Wilfried Tsonga completed a 6-2, 4-6, 6-2, 6-1 victory over German Cedrik-Marcel Stebe after their match was suspended because of rain on Wednesday, while sixth-seeded Spaniard David Ferrer whipped Frenchman Benoit Paire 6-3, 6-3, 6-2 to secure a spot in the round of 32 for an eighth consecutive year.

Twelfth-seeded Spanish clay-court specialist Nicolas Almagro took care of former Aussie Open runner-up Marcos Baghdatis of Cyprus 6-4, 6-3, 7-5, while 13th-seeded gritty Argentine Juan Monaco moved on by handling Czech Lukas Rosol 7-6 (7-4), 6-0, 7-6 (7-5).

In other second-round action involving seeds, No. 19 Canadian slugger Milos Raonic dismissed American Jesse Levine 6-4, 7-5, 6-2; No. 27 Russian Mikhail Youzhny topped Dutchman Robin Haase 6-3, 7-6 (7-5), 6-4; Italian Fabio Fognini knocked out No. 28 Serb Viktor Troicki 6-2, 3-6, 4-6, 6-3, 8-6; and the aforementioned Schwank drove out No. 32 German Florian Mayer 2-6, 6-3, 6-4 (7-4), 7-6 (7-4). Raonic will meet Monaco in his next outing, while Youzhny will face Ferrer in the round of 32.

Veteran French crowd favorite Arnaud Clement lost to Belgian David Goffin 3-6, 7-6 (7-2), 0-6, 6-2, 6-1 in a match that was suspended because of rain Wednesday with Goffin leading 5-1 in the fifth set.