Serena Williams lost in the first round of a major tournament for the first time, falling to Virginie Razzano of France 4-6, 7-6 (5), 6-3 Tuesday at the French Open.
The fifth-seeded Williams was two points from victory several times in the second set, including leading 5-1 in the tiebreaker. But Razzano won six straight points to force a third set, and then took control.
Williams entered the day with a 46-0 record in first-round matches at Grand Slam tournaments. She had been looking for her 14th major title, and second at Roland Garros.
Razzano won on her eighth match point.