A goal from Gregory van der Wiel in the 78th minute handed Ajax a 2-1 win at Twente on Sunday that just about wraps up a second straight Eredivisie crown for the Amsterdam side.
Theo Janssen put the visitors ahead on the half-hour mark when he converted from the penalty spot after Twente goalkeeper Nikolay Mihaylov had brought down Van der Wiel inside the area.
Leroy Fer hauled the hosts back to level terms in the 72nd minute when he finished off Nacer Chadli's corner kick, but the score remained 1-1 for just six minutes.
Lorenzo Ebecilio served a ball into the box that Van der Wiel drilled past Mihaylov to take his team to the brink of the title.
Ajax owns a six-point lead on second-place Feyenoord with two games to play, while also holding a 24-goal advantage in goal difference.
The club can officially clinch the title with a point at home against Venlo on Wednesday, but should still be crowned champions even with losses in its last two matches.
Feyenoord may have little chance of rallying to win the title but the club secured an important 1-0 home win against AZ Alkmaar on Sunday to move into second place.
The lone goal came in the 54th minute from Otman Bakkal and it moved Feyenoord three points clear of AZ and one above PSV Eindhoven for second.
PSV kept pace with Feyenoord after claiming a 3-1 win at Roda on Sunday, while the other match of the day saw NEC and RKC Waalwijk end in a 1-1 draw as the two sides traded goals early in the second half.