Derek Jeter and Raul Ibanez each homered and drove in three runs to lead the Yankees over the Angels, 11-5, in the rubber match of a three-game series.
Robinson Cano scored three runs and Nick Swisher drove in a pair for New York, which was coming off Saturday's 7-1 setback.
Ivan Nova (2-0) earned the win after allowing four runs on eight hits over six innings, while his counterpart, Jerome Williams (0-1), didn't make it out of the third inning in his first start of the season.
Williams was tagged for five runs on five hits and three walks in 2 2/3 innings as the Angels fell to 3-6 on the year.
Mark Trumbo and Chris Iannetta each homered in defeat.