With one out, Frazier and Francisco homered. Willie Harris singled and scored on Ryan Ludwick's double. LaMarre's two-run homer capped the rally.
Carlos Santana and Asdrubal Cabrera homered off Reds opening day starter Johnny Cueto. Cueto went six innings, allowing two runs and four hits in his last start before opening day.
Jeanmar Gomez left the game with a mildly strained hip after 3 2/3 innings.
The Cleveland pitcher stretched for a return throw from shortstop Cabrera to complete a double play in the bottom of the fourth inning.
Gomez is the third Indians pitcher to get hurt in two days. Derek Lowe left his start Thursday with a sore back and David Huff injured his hamstring later in that game.
Huff and Gomez were in the mix for the fifth starter job.