World No. 1 Novak Djokovic began his Sony Ericsson Open title defense with a 6-4, 6-4 second-round victory over Cypriot Marcos Baghdatis in Saturday's nightcap.
The Serb failed to defend his 2011 championships at Dubai and Indian Wells, but will have another chance at this ATP Masters event as he seeks his third Miami crown. He also won in 2007.
Earlier, Roger Federer and Andy Roddick, two other former champions here, set up a third-round clash after they both emerged victorious.
Federer, seeded third here and the winner of back-to-back titles in 2005 and 2006, bested American wild card Ryan Harrison 6-2, 7-6 (7-3), surviving a second-set tiebreaker after cruising in the first set.
The Swiss former world No. 1 will take on 31st-seeded Roddick, another player formerly at the top of the world rankings.
The 29-year-old American, a titlist in 2004 and 2010, rolled past Luxembourg's Gilles Muller 6-3, 6-2 in a tidy 73 minutes, firing 10 aces in the process.
In other action involving top-16 seeds, fifth-seeded Spaniard David Ferrer knocked out Aussie Bernard Tomic 6-4, 6-4, eighth-seeded American Mardy Fish defeated Canadian Frank Dancevic 6-3, 7-6 (7-1), and 11th-seeded Argentine Juan Martin Del Potro ousted Croatia's Ivo Karlovic 7-5, 6-4.
Additionally, 12th-seeded Nicolas Almagro repelled Belgian qualifier David Goffin 6-4, 6-2, 14th-seeded Frenchman Gael Monfils vanquished Ukranian qualifier Sergei Bubka 6-4, 6-4, and Albert Ramos of Spain subdued his countryman, 15th-seeded Feliciano Lopez, 6-4, 7-6 (7-5)
Meanwhile, France's 17th-seeded Richard Gasquet outlasted Cedrik-Marcel Stebe of Germany 6-3, 6-7 (6-8), 6-2, 20th-seeded Fernando Verdasco of Spain routed German qualifier Bjorn Phau 6-3, 6-0, and Juan Monaco, the 21st seed, advanced when Yen-Hsun Lu of Taiwan retired at 5-0 in favor of the Argentine.
Rounding out the day's matches, 23rd-seeded Marin Cilic of Croatia advanced past Russia's Igor Kunitsyn in 6-3, 7-6 (7-1) fashion, Serbian No. 27 seed Viktor Troicki survived 4-6, 6-1, 6-4 over Spanish qualifier Guillermo Garcia-Lopez, 28th-seeded Russian Kevin Anderson bounced American Sam Querrey 6-3, 6-7 (3-7), 6-3 and 30th-seeded Frenchman Julien Benneteau handled German Benjamin Becker 3-6, 6-3, 7-6 (7-4).
The winner of this lucrative $3.973 million tournament will claim $659,775.