Blake Griffin netted a game-high 20 points to go with 10 rebounds and five assists as the Clippers rolled past the Grizzlies, 101-85, on Saturday.
Chris Paul scored 19 points while handing out 13 assists, Randy Foye supplied 18 points and Nick Young had 16 off the bench for Los Angeles, which opened a five-game homestand by snapping a three-game skid.
The Clippers had lost all three games on a back-to-back-to-back road trip.
Zach Randolph led the way with 14 points and O.J. Mayo posted 13 for Memphis, which has lost all three contests on its current four-game trek and has dropped five of six overall.