Eugeneia McPherson scored a game-high 21 points, 70 win over Oklahoma in the second round of the NCAA Tournament at the Lloyd Noble Center.
Shenneika Smith contributed 18 points for the third-seeded Red Storm (24-9), followed by Nadirah McKenith and Da'Shena Stevens chipped in 13 and 11 points, respectively.
The sixth-seeded Sooners (21-13) were paced by Whitney Hand with 16 points, seven rebounds and seven assists, while Nicole Griffin and Morgan Hook 12 and 10 points, respectively.
Oklahoma shot an impressive 56.5 percent from the field in the first half and also knocked down all nine chances at the free-throw line in the period, yet the squad still trailed by three points at the break, 39-36.
In the second half the Sooners were able to battle back and post a three-point lead of their own just over three minutes into the frame, but the locals made a total of just 10 field goals in the period, allowing the Red Storm to surge for the four-point win.
In a game that experienced 13 ties and eight lead changes, Oklahoma hurt itself with 19 turnovers as it was turned back from making the Sweet 16 for the fourth straight campaign.
St. John's had never made it to the round of 16 before tonight and is now set to take on Duke, the second seed in the Fresno Region, this weekend.