Jrue Holiday and Thaddeus Young tallied 20 80 victory over the Charlotte Bobcats at Time Warner Cable Arena on Monday.
Lou Williams added 19 points and five assists, Elton Brand scored 16 and Spencer Hawes recorded a double-double with 13 points and 11 rebounds to snap a three-game losing streak for the Sixers.
Gerald Henderson led the Bobcats with 14 points, while Kemba Walker and Reggie Williams both finished with 13 points. Williams was starting for Bobcats' leading scorer Corey Maggette, who sat out the tilt with a back injury.
With the win, the Sixers swept the Bobcats for the first time since Charlotte's inaugural campaign in 2004-05.
Holiday had it going in the first as he led all scorers with 10 points to give the Sixers a 25-19 edge after one.
Philadelphia led for most of the second, but Charlotte got over the hump late in the frame as D.J. White capped a 6-0 spurt to put the Bobcats on top, 39-37, with 2:14 to play.
Young finished a putback dunk just before the halftime buzzer to give the visitors a slim 46-44 lead at the break.
Henderson finished a layup to tie the game to open the third, but the Sixers reeled off a 12-2 run to regain control, leading 58-48 with just under seven minutes to play.
The Bobcats never fully recovered, as the Sixers led by as many as 14 in the quarter and owned a 76-63 advantage heading into the final frame.
The Sixers used an 8-0 run in the fourth to press the lead to 21, 90-69, and Philadelphia held the Bobcats at arms length the rest of the way to complete the road victory.
Philadelphia will host New York on Wednesday, while the Bobcats will welcome Milwaukee on Friday to wrap up a three-game homestand...The Sixers dominated the paint, outscoring the Bobcats 50-26 in the lane, and holding a 51-31 advantage on the glass.