Dwight Howard posted another double-double with 94.
J.J. Redick, making his 10th start of the season, added 18 points and a career-high nine assists, while Ryan Anderson finished with 12 points and nine rebounds in Orlando's fourth win in five games.
Indiana, coming off an overtime loss to the Heat on Saturday, shot just 1- of-12 from behind the arc, while the Magic made 10 three-pointers.
Paul George led the Pacers with 22 points and eight rebounds, and Danny Granger netted 18 in the club's fourth straight loss.
The margin reached 24 shortly thereafter when Redick and fellow Duke alumnus Chris Duhon made three-pointers to push the lead to 50-26.
The Pacers cut the deficit to 56-45 by halftime, but Howard went off for 15 points in the third quarter to help put the game away. The All-Star center threw down an alley-oop dunk midway through the third to make it 71-53.
Indiana made just one field goal over the final 4 1/2 minutes of the quarter, and the Magic were able to cruise to the finish line holding a 91-66 cushion entering the final 12 minutes.
Orlando won the season series, 3-1...Quentin Richardson scored 10 points starting in place for Turkoglu, who was suspended one game for making contact with official Karl Lane in a win over Chicago on Thursday...Indiana's Tyler Hansbrough scored 13 of his 19 points in the fourth quarter.