The Pacers had six players score in double digits and pushed their season-high winning streak to six games.
Darren Collison added 13 points, Lou Amundson and Paul George had 11 apiece and George Hill scored 10 in the victory. Amundson had a double-double in 16 minutes off the bench, getting 10 rebounds.
"We just took care of our business. I'm proud of the guys and happy about the win," said Pacers coach Frank Vogel. "We're playing unselfish and that's part of our identity."
The banged-up and weary Hornets were led by Jarrett Jack's 18 points and 15 from Marco Belinelli. They were coming off a 97-92 win over Dallas on Friday, but saw no carry-over momentum in their fourth game in five nights.