Derrick Rose scored a game-high 32 points, ahead bucket with 19.4 seconds remaining, and the Chicago 95, on Tuesday.
Joakim Noah and Luol Deng each contributed double-doubles, as Noah scored 15 points and grabbed 16 rebounds, while Deng finished with 14 and 11. Carlos Boozer added 14 points for the Bulls, who have won three straight and five of their last six.
A balanced but ultimately unsuccessful New Orleans attack was paced by Chris Kaman's 17 point, 11 rebound double-double. Five other Hornets scored in double figures, including Trevor Ariza's 16 points. Greivis Vasquez and Xavier Henry netted 12 apiece, while Solomon Jones and Jarrett Jack each had 10 for the visitors, who dropped their third game in their last four.