Niklas Kronwall scored and added a pair of 2, at Nationwide Arena.
Johan Franzen, Henrik Zetterberg, and Valtteri Filppula finished with a goal and an assist apiece, and Jan Mursak also scored for the Red Wings, who snapped a three-game slide. Joey MacDonald made 28 saves in the victory.
Rick Nash and Derek MacKenzie scored for the Blue Jackets, who have lost three straight and five of six. Curtis Sanford was tagged for all five goals on 25 shots in defeat.