Tim Duncan had 18 points and 13 rebounds, 95 win over the Pistons on Tuesday.
Tony Parker scored eight of his 14 points in the fourth quarter for the Spurs, who won their eighth straight and improved to 4-0 on their annual Rodeo Road Trip.
The Pistons trailed by 16 in the third quarter, but battled back to grab an 85-83 lead late in the fourth. They couldn't hang on, however, and dropped their second straight game.
Despite the loss, Detroit's Ben Wallace celebrated a milestone, appearing in his 1,055th career game -- a record for an undrafted NBA player.