James scored 16 of his 35 points in the third quarter, punctuating the effort by racing past three defenders for a thunderous one-handed dunk that put the NBA's second-leading scorer over 30 points for the first time in five games.
The Heat moved to 6-1 since their most recent loss to the Bucks on February 1 and are 2-0 on their tough back-to-back-to-back stretch of three road games in three nights. They are 3-1 overall on a season-long six-game road trip.
"We took last night like it was its own game and we did the same thing tonight," said James. "Now we move on to Indiana to close it out."
Staying in the win column may not be that difficult, as the Heat beat the Pacers by 35 earlier in the year and have won three straight, seven of eight and eight of the last 11 in the series. Miami has also won three in a row in Indiana after losing 14 straight there.
Dwyane Wade has been particularly effective in Indiana of late, netting more than 40 points in each of his last two visits there.
The Pacers lost their season-high third straight game on Saturday, falling to the Denver Nuggets, 113-109.
Danny Granger led the way for the Pacers with 26 points and David West chipped in 22 points and seven rebounds. A.J. Price scored 13 points off the bench for a Pacers team that has now dropped four of their last five games.
"We played hard tonight. But they played a little harder and executed a little better," said Price. "We know we can bounce back. We have not face this, this year. But we know that we're up to it."