Each of Griffin's fellow starters scored in double figures, with Chris Paul netting 18 points and 14 assists, Caron Butler picking up 16 points, Randy Foye adding 12, and DeAndre Jordan finishing with 11 points and 12 boards.
Los Angeles won its second game in as many nights and their fourth in five tries on its current six-game road trip, which ends Monday at Dallas.
Kemba Walker continued his impressive rookie campaign, pacing Charlotte with 19 points. Corey Maggette added 12 and six rebounds and Tyrus Thomas had 11 points off the bench for the Bobcats, who set an unfortunate franchise record with their 14th consecutive loss.
Charlotte kept it close early, and the game was tied at eight near the midpoint of the first quarter. The Clippers rolled off the next seven points, however, capped off by a Jordan putback slam. Los Angeles built an advantage its would hold throughout the remainder of the contest.
The Clippers, who won at Philadelphia on Friday, led 24-16 after the first quarter, thanks in part to Charlotte shooting 6-of-21 from the field. LA was up 55-37 at halftime, and 84-52 after three quarters.
Maggette made his first start after missing 19 games this season with a strained left hamstring...The Clippers defeated Charlotte by the largest margin in team history. Los Angeles' previous best was a 15-point victory on January 29, 2011 at Staples Center...The Clippers scored 50 points in the paint and led by as many as 34...Charlotte shot 35.1 percent (26-of-74) from the field and 7.1 percent (1-of-14) from three-point range.