Shenise Johnson scored 19 points and Florida as it defeated No. 22 37, at BankUnited Center on Wednesday.
The Hurricanes (21-3, 10-1 ACC) also got 10 points from Stefanie Yderstrom as they won their 38th straight home game and 10th in a row overall.
Laura Broomfield had seven points and six rebounds and Chay Shegog added six points and six boards for North Carolina, (17-7, 7-4) which has lost two straight after winning its previous five.
Miami-Florida jumped out on a 17-4 run over the first eight minutes of the game, as the Hurricanes maintained a 32-22 lead at halftime.
The Tar Heels missed both of their three-point attempts, while the Hurricanes hit 4-of-10 from long range in the first half.
The Hurricanes used 35 Tar Heel turnovers to create 39 points off turnovers as they cruised to a 24-point victory.