Shenise Johnson had a double-double with Florida ran over Clemson, 68-47, at BankUnited Center on Sunday.
The Hurricanes (20-3, 9-1 ACC) got a 15-point effort from Riquna Williams as they ripped off their ninth straight victory and their 37th straight home victory.
Clemson (6-15, 2-8) was led by Nikki Dixon, who scored 16 points and pulled down six boards. Lindsey Mason added six points and 10 rebounds for Clemson, which has now lost five of its last six games.
The Hurricanes pulled off a 17-1 run in the first half as they took a 31-18 advantage going into halftime.
Miami-Florida outrebounded Clemson, 51-38, which led to it owning a 20-9 advantage in second-chance points as the Hurricanes cruised to victory.