The first goal of the game went to the Kings at the 5:26 mark of the second period when Kopitar banged home a rebound at the right side off a Dustin Brown shot.
With just 6:25 left in the second, though, the Avs tied the game as Stefan Elliott sent a perfect saucer pass from his own zone to the Kings' blueline where McLeod was behind the defense and put the puck in.
With 1:05 to play in the second, Colorado took a 2-1 lead as T.J. Galiardi fired a shot on net from the slot that was tipped in by Mueller.
Colorado was able to seal the win with 1:57 to play on the man advantage. Landeskog held the puck at the top of the left circle and sent it over to Paul Stastny at the right circle. Stastny held the puck for a moment before feeding it back to the slot where Landeskog wristed it home.
Los Angeles, which has lost three straight at home, hosts Ottawa on Monday...Colorado plays in Anaheim on Sunday...Colorado has won all three against Los Angeles this season. Last season, the Kings took all four matchups with the Avs.