The Maple Leafs had won a season-high four straight games before losing regulation decision against Buffalo, the Rangers and Ottawa. It is Toronto's fourth three-game slide of the year, but the first one with all three losses coming in regulation.
Toronto, which is three points behind Florida and Pittsburgh for the final two playoff spots in the Eastern Conference, hasn't dropped four in a row since an 0-3-1 stretch from Nov. 26-Dec. 2 of last season.
The Wild have also lost three straight (0-2-1) and are just 2-10-4 in their last 16 trips to the ice. Minnesota is currently ninth in the Western Conference with 51 points after leading the NHL with 43 points on Dec. 10.
Toronto scored the first two goals in Tuesday's game against visiting Ottawa, but the Sens scored three unanswered goals and Craig Anderson made 37 saves to lift the visitors to a 3-2 decision.
"We let them hang around," Lombardi said. "They took advantage of their opportunities and stuck with it. We got away from our game a few times and it bit us in the end."
Toronto has lost the first two tests on a five-game homestand and is 12-7-4 as the host this season.
Minnesota, meanwhile, played Tuesday night in Philadelphia and was dealt a 5-1 setback by the Flyers, who went 2-for-6 on the power play and outshot the Wild, 34-26.
"Bad things happened to us when we were in first place and we were winning a lot of hockey games [because] we overcame them. Right now we let those affect us in a very negative way," said Wild head coach Mike Yeo.
Minnesota is just 10-11-4 as the visiting team this season and is completing a four-game road trip tonight. The Wild's last road win came on Dec. 10 at Phoenix and the club is 0-8-2 as the guest since then.
Tonight's tilt marks the one scheduled meeting between the Wild and Leafs this season. Toronto posted a 3-0 win in St. Paul last year and has taken six of the nine all-time meetings in this series. The Wild earned their first-ever win in Toronto when the clubs last met at the ACC on Nov. 10, 2009.