Jason Pominville scored the game-winning goal 2 at First Niagara Center.
Paul Gaustad finished with a goal and an assist, while Matt Ellis also scored and Patrick Kaleta added a pair of assists for the Sabres, who snapped a three-game losing streak. Ryan Miller was strong in net, making 24 saves on 26 shots in the victory.
Mikhail Grabovski contributed a goal and an assist and Joey Crabb lit the lamp for the Maple Leafs, who had a four-game winning streak halted. Jonas Gustavsson stopped 22-of-25 shots in the loss for Toronto.