Jaquon Parker scored 21 points and pulled 63, at the Petersen Events Center.
Sean Kilpatrick tallied 19 points and Dion Dixon 13 for the Bearcats (11-3, 1-0 Big East), who took their conference opener while dealing the Panthers their third consecutive defeat.
Nasir Robinson had 19 points and 10 rebounds for Pittsburgh (11-4, 0-2), which could have tied the game in the closing seconds, but Ashton Gibbs and Lamar Patterson both missed three-point shots.
Patterson totaled 13 points and Dante Taylor had 11 boards for the Panthers, who opened Big East play with a 72-59 loss at Notre Dame on Tuesday. Sunday marked Pitt's third loss in its last 30 Big East Conference home games and just their fifth defeat in its last 67 as the host team.