Mike Glennon threw three touchdown passes and 24, to win the 2011 Belk Bowl.
Glennon passed for 265 yards with an interception on 21-of-33 throws for the Wolfpack (8-5), who won four of their last five to finish the season.
T.J. Graham caught seven passes for 115 yards and two scores for the victors.
Louisville's Teddy Bridgewater threw for 273 yards and two touchdowns, but was intercepted three times, one of which David Amerson returned for a score.
The Cardinals (7-6) won five of their last six regular season games to earn a share of the Big East title.