Cory Emmerton scored twice and added an assist 2, at Joe Louis Arena.
Niklas Kronwall, Henrik Zetterberg, Pavel Datsyuk and Brad Stuart also scored for Detroit, which extended its home winning steak to 10 games. It is the Red Wings' first 10-game home win streak since the 2006-2007 season.
Jimmy Howard made 27 saves in the win.
Earlier in the day, Darryl Sutter reportedly agreed to become the Los Angeles Kings' next head coach and is likely to be introduced on Tuesday or Wednesday.