Claude Giroux scored with 2:23 remaining in 4.
Giroux was able to gain control of the puck inside his own zone and was allowed space up the middle of the ice. He broke free and cruised to the Sabres goal, beating Ryan Miller through the pads to end the game.
It capped a four-point contest for the 23-year-old, who helped Philadelphia recover from a 3-0 deficit in the first period and vaulted into the NHL scoring lead.
Ilya Bryzgalov shook off a poor first period to make 20 saves in the win.