Nasir Robinson's double-double of 16 points 56 victory over Tennessee Boling Arena.
Ashton Gibbs also scored 16 points for the Panthers (7-1), who got eight points apiece from Lamar Patterson, Dante Taylor and John Johnson.
Pittsburgh has won five straight since an 86-76 loss to Long Beach State on November 16.
Cameron Tatum had 13 points and 10 rebounds for the Volunteers (3-4), who have dropped four of five. Jeronne Maymon and Trae Golden both contributed 12 points in defeat.