Vick will miss his second consecutive game because of two broken ribs he suffered on the second play of the team's Week 10 loss to the Arizona Cardinals.
Vince Young will make his second straight start in place of Vick. He led the Eagles on the game-winning, 18-play drive late in the fourth quarter against the Giants last Sunday.
Maclin (hamstring) and Rodgers-Cromartie (ankle) will also miss their second consecutive games.
Cornerback Nnamdi Asomugha will start against New England despite being carted off the field during Thursday's practice with a hyperextension of his left knee. He sat out practice on Friday.